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The only independent pharmacokinetic study (Xu 2022) reported plasma half-lives of approximately 15 minutes intravenous in rat and 5 minutes intravenous in beagle dog, with bioavailability of 14-19% in rats and 45-51% in dogs and no drug accumulation across 7 days of repeated dosing [7]

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Second, Alpha interferon which is a type of interferon 1 can cause tolerance disruption of myelin sheath antigen (222)